Acetic Acid → HCID 68901947、化合物

HRID 1987701ノート

反応式

HRID 1987701 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)([O-:3])=[O:2].[I:15]N1C(=O)CCC1=O.C(O)(=O)C>CO>[I:15][C:12]1[S:11][C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 120273N-IodosuccinimideHCID 91672612-(2-nitrophenyl)thiophene

生成物 1

HCID 68901947HCID 68901947、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(2-nitro-phenyl)-thiophene (23 g, 0.11 mol) and N-iodosuccinimide (37 g, 0.165 mol) were dissolved in 110 ml of methanol. To this solution, acetic acid (10 g, 0.165 mol) was added. After stirring the reaction mixture for 4 hours at room temperature, the solvent was evaporated. The remainder was taken up in a mixture of ice and water and extracted with ethyl acetate. The combined organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over magnesium sulfate and evaporated, delivering 2-iodo-5-(2-nitro-phenyl)-thiophene (28 g).

後処理

  1. customthe solvent was evaporated
  2. additionThe remainder was taken up in a mixture of ice and water
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-abb13ff22a104882a68ed815deb540ba
出典データセット
uspto-grants-2009_06
特許番号
US07553798B2

反応ノート

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