Hydrazine hydrate (1:1) → (2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanohydrazide
反応式
[F:1][C:2]([F:11])([F:10])[C@:3]([OH:9])([CH3:8])[C:4](OC)=[O:5].O.[NH2:13][NH2:14]>>[F:1][C:2]([F:11])([F:10])[C@:3]([OH:9])([CH3:8])[C:4]([NH:13][NH2:14])=[O:5]参加物
3
反応条件
- 温度
- 130 °C
実験手順
To a solution of methyl(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoate (3.26 g, 19.0 mmol) was added hydrazine monohydrate (2.1 ml). The mixture was heated at 130° C. for 90 min and cooled down to room temperature. After evaporation to dryness, the residue was purified on a small bed of silica gel (100% EtOAc) to afford the title compound.
後処理
- temperaturecooled down to room temperature
- customAfter evaporation to dryness
- customthe residue was purified on a small bed of silica gel (100% EtOAc)
出典と根拠
- ORDレコード
- ord-f213fe6f37f14c8ebe6353f69db09351
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07553973B2
反応ノート
読み込み中…