HCID 131727514、化合物 → HCID 57729134、化合物

HRID 1988245ノート

反応式

HRID 1988245 の反応式
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:11]([N:13]([CH3:40])[C@H:14]([C:18]([N:20]([CH3:39])[C@H:21]([C:34]([NH:36][O:37][CH3:38])=[O:35])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([C:30]([CH3:33])([CH3:32])[CH3:31])[CH:24]=1)=[O:19])[CH:15]([CH3:17])[CH3:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:1][C@H:2]([C:11]([N:13]([CH3:40])[C@H:14]([C:18]([N:20]([CH3:39])[C@H:21]([C:34]([NH:36][O:37][CH3:38])=[O:35])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([C:30]([CH3:33])([CH3:31])[CH3:32])[CH:24]=1)=[O:19])[CH:15]([CH3:17])[CH3:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1

参加物

4

反応物 1

HCID 131727514HCID 131727514、化合物

生成物 1

HCID 57729134HCID 57729134、化合物収率 34.2%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

To a solution of Boc-Phe(4-F)-N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe (972 mg, 1.508 mmol) in methylene chloride (10 ml), TFA (7 ml) was added and stirred for 30 min. The mixture was concentrated under reduced pressure and the thus obtained residue was subjected to silica gel column chromatography (developing solvent: methylene chloride:methanol=20:1), giving the titled compound (288 mg, 34%).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1811e7c164f24367bb3c42a1be7b31ee
出典データセット
uspto-grants-2009_06
特許番号
US07553969B1

反応ノート

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