Thioacetamide → 2-Chloro-5-(2-methyl-thiazol-4-yl)-benzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([C:10](=O)[CH2:11]Br)[CH:7]=[CH:6][C:5]=1[Cl:14].[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([C:10]2[N:19]=[C:16]([CH3:17])[S:18][CH:11]=2)[CH:7]=[CH:6][C:5]=1[Cl:14]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 5-(2-bromo-acetyl)-2-chloro-benzoic acid methyl ester (25 mg, 0.09 mmol) and thioacetamide (6.5 mg, 0.08 mmol) in ethanol (2 mL) and stirred at 50° C. for 15 minutes. The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in ethyl acetate, washed with water, and brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound (10 mg).
後処理
- temperatureThe mixture was cooled to room temperature
- concentrationconcentrated in vacuo
- dissolutionThe residue was dissolved in ethyl acetate
- washwashed with water, and brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-6d8bc77bbe0e40ecadc94596b44d9cec
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07553972B2
反応ノート
読み込み中…