Diisopropylethylamine → N-methyl-4-(2-(4-((4-methylpiperazin-1-yl)methyl)benzylamino)benzo[d]thiazol-6-yloxy)picolinamide

HRID 1988478

反応式

[CH3:1][NH:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:22]=[CH:21][C:14]3[N:15]=[C:16](S(C)=O)[S:17][C:13]=3[CH:12]=2)[CH:7]=[CH:6][N:5]=1.[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([CH2:38][NH2:39])=[CH:34][CH:33]=2)[CH2:27][CH2:26]1.CCN(C(C)C)C(C)C>CN1C(=O)CCC1>[CH3:1][NH:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:22]=[CH:21][C:14]3[N:15]=[C:16]([NH:39][CH2:38][C:35]4[CH:34]=[CH:33][C:32]([CH2:31][N:28]5[CH2:27][CH2:26][N:25]([CH3:24])[CH2:30][CH2:29]5)=[CH:37][CH:36]=4)[S:17][C:13]=3[CH:12]=2)[CH:7]=[CH:6][N:5]=1

参加物

反応条件

温度: 80 °C

実験手順

To the solution of N-methyl-4-(2-(methylsulfinyl)benzo[d]thiazol-6-yloxy)picolinamide (25 mg, 0.072 mmol, 1.0 eq) in 2 mL of NMP was added (4-((4-methylpiperazin-1-yl)methyl)phenyl)methanamine (23 mg, 0.108 mmol, 1.5 eq) and DIPEA (37 μL, 0.216 mmol, 3.0 eq) and reaction mixture heated at 80° C. in oil bath for 12 hours. Thereafter, the product was purified via reverse phase HPLC. LC/MS (m/z) [503.1] (MH+).

後処理

customThereafter, the product was purified via reverse phase HPLC

出典と根拠

ORDレコード: ord-663d11ea073447a2920cb78d1f4eab3c
出典データセット: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07553854B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート