To a solution of 8-indan-5-yl-2-[4-(2-morpholin-4-yl-ethyl)-phenylamino]-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (Example 27 (b), 20 mg, 0.037 mmol) in 1 mL methanol was added a solution of ethylamine in THF (2N, 2 mL). The mixture was stirred at 80° C. for 16 hours. The solvent was removed by vacuum to leave a yellow solid (12.7 mg, 64%). 1H NMR (400 MHz, CDCl3) δ (ppm): 10.60 (br, 1H), 9.29 (s, 1H), 8.78 (s, 1H), 7.75 (s, 1H), 7.60 (br, 1H), 7.34 (d, J=7.6 Hz, 1H), 7.20 (m, 2H), 7.12 (d, J=7.6 Hz, 1H), 6.87 (br, 2H), 3.69 (br, 4H), 3.42(q, J=7.1 Hz, 2H), 3.01 (t, J=7.3 Hz, 2H), 2.93 (t, J=7.4 Hz, 2H), 2.65 (br, 2H), 2.49 (br, 6H), 2.17 (m, 2H). 1.08 (t, 7.1 Hz, 3H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C31H34N6O3: 539.27 (M+H), Found 539.0.
