Sodium borohydride → HCID 68526007、化合物
反応式
[BH4-].[Na+].[CH2:3]([O:5][C:6]([C:8]1[S:9][C:10](SC)=[C:11]([C:20]#[N:21])[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([I:19])=[CH:15][CH:14]=1)=[O:7])[CH3:4]>CCO>[CH2:3]([O:5][C:6]([C:8]1[S:9][CH:10]=[C:11]([C:20]#[N:21])[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([I:19])=[CH:15][CH:14]=1)=[O:7])[CH3:4]参加物
4
実験手順
Add NaBH4 (0.26 mmol) to a solution of 3-(4-iodophenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester, prepared in example E-3, in 2 mL of EtOH at 0° C. Remove the ice-bath and stir at room temperature. After 30 min, add additional NaBH4 (0.26 mmol) and stir and additional 30 minutes. Remove the solvent in vacuo and extract the residue with 50 mL of 1/9 MeOH/CH2Cl2. Evaporate and chromatograph (hexane:ethyl acetate 3:1) over silica gel to provide the title compound: MS (ES+, m/e): 384 (M+1).