(3-Ethoxy-5-isobutoxy-phenyl)-methanol → 3-Ethoxy-5-isobutoxy-benzaldehyde

HRID 1990849ノート

反応式

HRID 1990849 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:15][OH:16])[CH:7]=[C:8]([O:10][CH2:11][CH:12]([CH3:14])[CH3:13])[CH:9]=1)[CH3:2]>CN(C=O)C.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[C:8]([O:10][CH2:11][CH:12]([CH3:13])[CH3:14])[CH:9]=1)[CH:15]=[O:16])[CH3:2]

参加物

4

反応物 1

HCID 68694893(3-Ethoxy-5-isobutoxy-phenyl)-methanol

生成物 1

HCID 587063263-Ethoxy-5-isobutoxy-benzaldehyde収率 100.8%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To a solution of (3-ethoxy-5-isobutoxy-phenyl)-methanol (0.28 g, 1.25 mmol, 1.0 equiv) in DMF (20 mL) was added activated MnO2 (1.09 g, 12.48 mmol, 10.0 equiv). The reaction mixture was heated to 60° C. for 2 h, filtered through Hyflo Super Cel and concentrated by evaporation under reduced pressure yielding 0.28 g (99% yield) of the title compound. MS (ISP): 223.0 [M+H]+.

後処理

  1. filtrationfiltered through Hyflo Super Cel
  2. concentrationconcentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-b4013a8a1e584b3f9476883d7a452734
出典データセット
uspto-grants-2010_01
特許番号
US07645753B2

反応ノート

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