Hydrazine hydrate (1:1) → HCID 59128632、化合物

HRID 1991017ノート

反応式

HRID 1991017 の反応式
[CH2:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:7](OC)=[O:8])[CH:2]=[CH2:3].O.[NH2:16][NH2:17]>C(O)C>[CH2:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:7]([NH:16][NH2:17])=[O:8])[CH:2]=[CH2:3]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 591286443-Allyl-4-methyl-benzoic acid methyl ester

生成物 1

HCID 59128632HCID 59128632、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of methyl 3-allyl-4-methylbenzoate (2.84 g, 15 mmol) and hydrazine hydrate (2.1 mL, 37.5 mmol) in ethanol (5 mL) was heated to 100° C. for 6 hours. After cooling, the mixture was partitioned between ethyl acetate and water, and the combined organic layers were washed with brine, dried (MgSO4), filtered, and concentrated under reduced pressure to give 3-allyl-4-methyl-benzoic acid hydrazide as a white solid. (Yield 2.80 g, 98.1%).

後処理

  1. temperatureAfter cooling
  2. customthe mixture was partitioned between ethyl acetate and water
  3. washthe combined organic layers were washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-7d235f74240e4359a99e3522c0402d53
出典データセット
uspto-grants-2010_01
特許番号
US07645764B2

反応ノート

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