Acetyl chloride → N-(2-Bromo-5-chloro-4-methoxyphenyl)acetamide

HRID 1991089ノート

反応式

HRID 1991089 の反応式
[Br:1][C:2]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([Cl:11])=[CH:5][C:3]=1[NH2:4].C(N(CC)CC)C.[C:19](Cl)(=[O:21])[CH3:20].C([O-])(O)=O.[Na+]>C1COCC1>[Br:1][C:2]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([Cl:11])=[CH:5][C:3]=1[NH:4][C:19](=[O:21])[CH3:20]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 451567062-Bromo-5-chloro-4-methoxybenzenamine

生成物 1

HCID 68535198N-(2-Bromo-5-chloro-4-methoxyphenyl)acetamide収率 69.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4.40 g (18.6 mmol) 2-Bromo-5-chloro-4-methoxy-aniline and 3.1 ml (22.0 mmol) triethylamine were dissolved in 50 ml THF. 1.42 ml (20.0 mmol) acetylchloride were added dropwise at room temperature. The reaction mixture was stirred at room temperature for additional 2 hours, saturated NaHCO3 solution was added and the mixture was extracted with ethyl acetate. Removal of the solvent and crystallisation with ether gave 3.6 g (12.9 mmol, 69%) of the title compound.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. customRemoval of the solvent and crystallisation with ether

出典と根拠

ORDレコード
ord-7277291a1405423487eb8888b8c9f8f1
出典データセット
uspto-grants-2010_01
特許番号
US07645760B2

反応ノート

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