Iodoethane → 6-nitro-3-ethyl-2(3H)-benzothiazolone

HRID 1991258ノート

反応式

HRID 1991258 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]2[NH:8][C:9](=[O:11])[S:10][C:6]=2[CH:5]=1)([O-:3])=[O:2].N12CCCN=C1CCC[CH2:16][CH2:15]2.ICC>CN(C)C=O.O>[N+:1]([C:4]1[CH:13]=[CH:12][C:7]2[N:8]([CH2:15][CH3:16])[C:9](=[O:11])[S:10][C:6]=2[CH:5]=1)([O-:3])=[O:2]

参加物

6

反応物 3

HCID 6340IodoethaneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 6415712(3H)-Benzothiazolone, 6-nitro-

生成物 1

HCID 122863766-nitro-3-ethyl-2(3H)-benzothiazolone

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of 6-nitro-2-benzothiazolinone (2.5 g, 12.7 mmol) in anhydrous N,N-dimethylformamide (25 mL) under N2 is treated with 1,8-diazabicyclo[5.4.0]undec-7-ene (2.48 mL, 16.6 mmol) dropwise followed by iodoethane (1.22 mL, 15.3 mmol). Following a slight exotherm, the reaction mixture is stirred at ambient temperature for 21 h, diluted with water (20 mL) and filtered to give the title compound, mp 200-203° C.

後処理

  1. filtrationfiltered

出典と根拠

ORDレコード
ord-8ac66565afbe43d4a971805255004947
出典データセット
uspto-grants-2010_01
特許番号
US07645781B2

反応ノート

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