Sodium Hydroxide → 4-(Methylsulfonamido)benzoic acid

HRID 1992236

反応式

HRID 1992236 の反応式
[OH-].[Na+].[CH3:3][S:4]([NH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]>CO.O>[CH3:3][S:4]([NH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 669159Methyl 4-methanesulfonamidobenzoate

生成物 1

HCID 2506534-(Methylsulfonamido)benzoic acid収率 74.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

3.6 g (90 mmol) of NaOH was added to the solution of methyl 4-[(methylsulfonyl)amino]benzoate in 40 mL methanol and 20 mL water and stirred overnight at room temperature. Solvents were then removed and the product purified by ethyl acetate extraction from 1N aqueous hydrochloric acid, providing 1.2 g (yield 74.6%) of the 4-[(methylsulfonyl)amino]benzoic acid. 1H NMR in d-chloroform: 8.03 (2H, d, J=8.7 Hz), 7.34 (2H, d, J=8.7 Hz), 3.09 (3H, s). 13C NMR in d-chloroform: 131.2, 117.9, 38.6.

後処理

  1. customSolvents were then removed
  2. customthe product purified by ethyl acetate extraction from 1N aqueous hydrochloric acid

出典と根拠

ORDレコード
ord-f82e1be2368949ec859bab25801deb71
出典データセット
uspto-grants-2010_01
特許番号
US07645771B2

関連ノート

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