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1-(Benzenesulfonyl)piperazine → (4-Benzenesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Benzenesulfonyl)piperazine | HCID 808712 | — |
| 反応物 | [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone | HCID 68538245 | — |
| 生成物 | (4-Benzenesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68535846 | 92% |
反応手順
The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and 1-benzenesulfonyl-piperazine to afford the desired product as a light-brown foam (92%). MS (ISP): 524.2 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07648979B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-8f7edb21f40146ef83d62e0a66e79c67 |
| 出典メモ | uspto-grants-2010_01 |