HRID1992465

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID808712

1-(phenylsulfonyl)piperazine

C10H14N2O2S

结构：CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCN(S(C)(=O)=O)CC4)cc3c2)CC1

HCID68538245

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCN(S(=O)(=O)c5ccccc5)CC4)cc3c2)CC1

HCID68535846

未命名化合物

收率 92%

PROCEDURE

实验过程

The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and 1-benzenesulfonyl-piperazine to afford the desired product as a light-brown foam (92%). MS (ISP): 524.2 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8f7edb21f40146ef83d62e0a66e79c67
来源数据集: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07648979B2
来源说明: uspto-grants-2010_01

反应 SMILES

[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([S:29]([CH3:32])(=[O:31])=[O:30])[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[C:33]1(S(N2CCNCC2)(=O)=O)[CH:38]=[CH:37]C=[CH:35][CH:34]=1>>[C:32]1([S:29]([N:26]2[CH2:25][CH2:24][N:23]([C:21]([C:16]3[NH:17][C:18]4[C:14]([CH:15]=3)=[CH:13][C:12]([C:10]([N:7]3[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]3)=[O:11])=[CH:20][CH:19]=4)=[O:22])[CH2:28][CH2:27]2)(=[O:30])=[O:31])[CH:37]=[CH:38][CH:33]=[CH:34][CH:35]=1