Sodium Hydroxide → 3-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)propan-1-ol

HRID 1992591ノート

反応式

HRID 1992591 の反応式
Cl.C([O:5][CH2:6][CH2:7][CH2:8][NH:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][N:18]=2)[N:13]=[CH:12][C:11]=1[NH:20][C:21](=O)[CH2:22][CH2:23][CH3:24])(=O)C.[OH-].[Na+]>C(O)C>[CH2:22]([C:21]1[N:9]([CH2:8][CH2:7][CH2:6][OH:5])[C:10]2[C:19]3[N:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]=[CH:12][C:11]=2[N:20]=1)[CH2:23][CH3:24]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 68537702HCID 68537702、化合物

生成物 1

HCID 685386673-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)propan-1-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To the 3-{[3-(butyrylamino)[1,5]naphthyridin-4-yl]amino}propyl acetate hydrochloride prepared in Part D was added ethanol (165 mL) and 2 M sodium hydroxide (62.0 mL, 124 mmol). The resulting solution was heated at 60° C. for 7 hours, and then was stirred at room temperature overnight. The solution was concentrated, and the resulting residue was dissolved in dichloromethane (250 mL) and washed with water (125 mL). The aqueous layer was extracted with dichloromethane (75 mL). The combined organic layers were washed with brine (100 mL), dried over magnesium sulfate, filtered, and concentrated to provide 9.24 g of 3-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)propan-1-ol as a brown oil.

後処理

  1. concentrationThe solution was concentrated
  2. dissolutionthe resulting residue was dissolved in dichloromethane (250 mL)
  3. washwashed with water (125 mL)
  4. extractionThe aqueous layer was extracted with dichloromethane (75 mL)
  5. washThe combined organic layers were washed with brine (100 mL)
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-cba24fc4eeab4f8685879301d4f9731c
出典データセット
uspto-grants-2010_01
特許番号
US07648997B2

反応ノート

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