Acetonitrile → (1-Amino-2-methylpropan-2-yl)phosphonic acid
反応式
CC#N.C([O:6][P:7]([C:12]([CH3:16])([CH3:15])[CH2:13][NH2:14])(=[O:11])[O:8]CC)C.C[Si](Br)(C)C>CO>[NH2:14][CH2:13][C:12]([P:7](=[O:6])([OH:11])[OH:8])([CH3:16])[CH3:15]参加物
5
実験手順
A solution of CH3CN (30 mL) of crude 6 (2.5 g) was cooled to 0° C., and treated with TMSBr (8 g, 52 mmol) for 5 hr. The reaction mixture was stirred with methanol for 1.5 hr at room temperature, concentrated, recharged with methanol, concentrated to dryness to give crude 7 which was used for next reaction without further purification.
後処理
- concentrationconcentrated
- concentrationconcentrated to dryness
- customto give crude 7 which
- customwas used for next reaction without further purification
出典と根拠
- ORDレコード
- ord-450613276df24dbeb25860721c6e1fa6
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07649015B2
反応ノート
読み込み中…