Propan-2-one--dichloromethane (1/1) → [6-(4-Amino-2-methyl-phenoxy)-pyrimidin-4-yl]-methyl-amine

HRID 1993586ノート

反応式

HRID 1993586 の反応式
C(OC(=O)[NH:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[C:22]([NH:24][CH3:25])[N:21]=[CH:20][N:19]=2)=[C:13]([CH3:26])[CH:12]=1)C1C=CC=CC=1.CC(C)=O.C(Cl)Cl>CO.C1COCC1.[Pd]>[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[N:19]=[CH:20][N:21]=[C:22]([NH:24][CH3:25])[CH:23]=2)=[C:13]([CH3:26])[CH:12]=1

参加物

5

反応物 2

HCID 21584124Propan-2-one--dichloromethane (1/1)HCID 68537615[3-Methyl-4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-carbamic acid benzyl ester

生成物 1

HCID 68537196[6-(4-Amino-2-methyl-phenoxy)-pyrimidin-4-yl]-methyl-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

The title compound is prepared from [3-methyl-4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-carbamic acid benzyl ester by hydrogenation in the presence of Pd/C in MeOH/THF: M+H=230.9; Rf (acetone/CH2Cl2=1:1): 0.20.

出典と根拠

ORDレコード
ord-0cada57be2d34d56b70d25b97fecebc7
出典データセット
uspto-grants-2010_01
特許番号
US07652022B2

反応ノート

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