関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Hydroxyindole | HCID 16054 | — |
| 反応物 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 反応物 | Propan-2-one--water (1/1) | HCID 18366337 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-((6-Chloropyrimidin-4-yl)oxy)-1H-indole | HCID 57455156 | — |
反応手順
To a mixture of NaOH (720 mg, 18 mmol) and acetone/water 1:1 (72 ml), 4,6-dichloropyrimidine (2.4 g, 18 mmol) and 5-hydroxy-indole (2.68 g, 18 mmol) are added. After stirring for 70 min at 65° C., the brownish solution is cooled to rt and diluted with AcOEt and water. The aqueous layer is separated off and extracted twice with AcOEt. The organic layers are washed with water, saturated Na2CO3 solution, water and brine, dried (Na2SO4) and concentrated. The crude product can be used without further purification: m.p.: 137-138° C.; MS: [M+1]+=246.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07652022B2 |
|---|
| 出典データセット | uspto-grants-2010_01 |
|---|
| ORD ID | ord-fda71291314b4954ab91941c4e258e26 |
|---|
| 出典メモ | uspto-grants-2010_01 |
|---|
