反应详情

温度

65 °C

To a mixture of NaOH (720 mg, 18 mmol) and acetone/water 1:1 (72 ml), 4,6-dichloropyrimidine (2.4 g, 18 mmol) and 5-hydroxy-indole (2.68 g, 18 mmol) are added. After stirring for 70 min at 65° C., the brownish solution is cooled to rt and diluted with AcOEt and water. The aqueous layer is separated off and extracted twice with AcOEt. The organic layers are washed with water, saturated Na2CO3 solution, water and brine, dried (Na2SO4) and concentrated. The crude product can be used without further purification: m.p.: 137-138° C.; MS: [M+1]+=246.

1. additionare added
2. temperaturethe brownish solution is cooled to rt
3. customThe aqueous layer is separated off
4. extractionextracted twice with AcOEt
5. washThe organic layers are washed with water, saturated Na2CO3 solution, water and brine
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated
8. customThe crude product can be used without further purification