Trifluoroacetic acid → 2-(4-Fluoro-2-methylphenyl)acetic acid
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C(C)(C)C)=[O:10])=[C:4]([CH3:16])[CH:3]=1.C(C(O)=O)(F)(F)F>C(Cl)Cl.C1(OC)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([CH3:16])[CH:3]=1参加物
5
実験手順
The pure ester was dissolved in 60 ml of CH2Cl2 was added 6 drops of anisole and 60 ml of CF3CO2H and the solution was atirred at rt for 16 hr. Upon removal of volatiles, the residue was dried three times by dissolving in toluene to afford 20.02 g of the title compound. 1H-NMR (CDCl3): δ 2.35 (s, 3H), 3.67 (s, 2H), 6.92-6.95 (m, 2H), 7.19 (d of d, 1H, J=8.2, 5.7 Hz) ppm.
後処理
- customUpon removal of volatiles
- customthe residue was dried three times
- dissolutionby dissolving in toluene
出典と根拠
- ORDレコード
- ord-0c524a293baa4cde985fe3030bad9514
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07652058B2
反応ノート
読み込み中…