Triethyl orthoacetate → 3-Methyl-6-phenyl[1,2,4]triazolo[4,3-a]pyrazine

HRID 1995062

反応式

HRID 1995062 の反応式
[NH:1]([C:3]1[CH:8]=[N:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][N:4]=1)[NH2:2].[C:15](OCC)(OCC)(OCC)[CH3:16]>>[C:9]1([C:6]2[N:7]=[CH:8][C:3]3[N:4]([C:15]([CH3:16])=[N:2][N:1]=3)[CH:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 66221Triethyl orthoacetateHCID 131998672-Hydrazinyl-5-phenylpyrazine

生成物 1

HCID 131998743-Methyl-6-phenyl[1,2,4]triazolo[4,3-a]pyrazine

実験手順

A solution of 0.5 g. (0.0027 mole) of 2-hydrazino-5-phenylpyrazine in 5.0 ml. of triethyl orthoacetate is heated under reflux for 5 hours. The crystalline product precipitates from the hot reaction solution, and at the end of the heating period the mixture is cooled and the product is collected. Recrystallization from ethanol gives 0.36 g. of the product of the example, m.p. 192°-195° C.

後処理

  1. temperatureunder reflux for 5 hours
  2. customThe crystalline product precipitates from the hot reaction solution
  3. temperatureat the end of the heating period the mixture is cooled
  4. customthe product is collected
  5. customRecrystallization from ethanol
  6. customgives 0.36 g

出典と根拠

ORDレコード
ord-d0914a405b454da587388b08131ff14a
出典データセット
uspto-grants-1983_09
特許番号
US04402958

関連ノート

読み込み中…