Hydrogen Bromide → 4-[4-(2-Thiazolyl)-1-piperazinyl]phenol
反応式
CO[CH:3]1[S:7][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[N:5][CH2:4]1.Br>>[S:7]1[CH:3]=[CH:4][N:5]=[C:6]1[N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=2)[CH2:12][CH2:13]1参加物
3
実験手順
A mixture of 4 parts of 4-[4-(4,5-dihydro-5-methoxy-2-thiazolyl)-1-piperazinyl]phenol and 150 parts of a hydrobromic acid solution 48% is stirred and refluxed for 12 hours. The reaction mixture is evaporated and the residue is dissolved in water. The precipitated product is filtered off and crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 2.5 parts (68%) of 4-[4-(2-thiazolyl)-1-piperazinyl]phenol; mp 169.9° C.
後処理
- temperaturerefluxed for 12 hours
- customThe reaction mixture is evaporated
- dissolutionthe residue is dissolved in water
- filtrationThe precipitated product is filtered off
- customcrystallized from 4-methyl-2-pentanone
- filtrationThe product is filtered off
- customdried
出典と根拠
- ORDレコード
- ord-f78206b856d54e5daabd368fc154ae4f
- 出典データセット
- uspto-grants-1983_09
- 特許番号
- US04402957
反応ノート
読み込み中…