Water → 2-Ethyl-[1,1'-biphenyl]-3-methanol

HRID 1995134ノート

反応式

HRID 1995134 の反応式
[CH2:1]([C:3]1[C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2].O>O1CCCC1.C(Cl)Cl>[CH2:1]([C:3]1[C:8]([CH2:9][OH:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2]

参加物

5

反応物 2

HCID 962WaterHCID 202706372-Ethyl-[1,1'-biphenyl]-3-carboxylic acid

生成物 1

HCID 202706032-Ethyl-[1,1'-biphenyl]-3-methanol収率 106.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 2-ethyl-[1,1'-biphenyl]-3-carboxylic acid (2.1 g, 0.0093 mole) in 50 ml of tetrahydrofuran was added dropwise borane-tetrahydrofuran complex (1.6 g, 0.0186 mole). The reaction mixture was stirred at room temperature for approximately 18 hours. Water (6 ml) was slowly added to the reaction mixture and the solvent removed under reduced pressure to give a residue. The residue was dissolved in methylene chloride; the solution was washed with 1 N aqueous sodium hydroxide, dried over anhydrous magnesium sulfate, and filtered. The filtrate was evaporated under reduced pressure to give 2-ethyl-[1,1'-biphenyl]-3-methanol (2.1 g) as an oil. The ir and nmr spectra were consistent with the named compound.

後処理

  1. customthe solvent removed under reduced pressure
  2. customto give a residue
  3. washthe solution was washed with 1 N aqueous sodium hydroxide
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-6c2f8a20848743ac92f7fcb16e96f6bf
出典データセット
uspto-grants-1983_09
特許番号
US04402973

反応ノート

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