Methane → 4-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione

HRID 1995381

反応式

HRID 1995381 の反応式
N[C:2]1[C:6]2[C:7]([OH:11])=[CH:8][CH:9]=[CH:10][C:5]=2[S:4](=[O:13])(=[O:12])[N:3]=1.[OH-:14].[Na+].C.Cl>O>[OH:11][C:7]1[C:6]2[C:2](=[O:14])[NH:3][S:4](=[O:13])(=[O:12])[C:5]=2[CH:10]=[CH:9][CH:8]=1

参加物

6

反応物 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1363022813-Amino-4-hydroxy-1,2-benzoisothiazole-1,1-dioxide

生成物 1

HCID 14865224-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione収率 92%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5 gm (25.2 mmols) of 3-amino-4-hydroxy-1,2-benzoisothiazole-1,1-dioxide and 2.02 gm (50.5 mmols) of sodium hydroxide were refluxed in 15 ml of water for 6.5 hours. Subsequently, the solution was treated with activated charcoal at 60° C. and filtered. At 60° C. the filtrate was acidified with concentrated aqueous hydrochloric acid (about 5 ml, 0.06 mol). The resulting precipitate was filtered off, dried and recrystallized from water. 4.62 gm (92% of theory) of 4-hydroxy-1,2-benzoisothiazol-3(2H)-one-1,1-dioxide were obtained.

後処理

  1. filtrationfiltered
  2. customAt 60° C.
  3. filtrationThe resulting precipitate was filtered off
  4. customdried
  5. customrecrystallized from water

出典と根拠

ORDレコード
ord-79c6259e31034bdcba1c8073e06a4e74
出典データセット
uspto-grants-1983_09
特許番号
US04404230

関連ノート

読み込み中…