Isobutylamine → 7-amino-2,2-dimethyl-8-(2-methylpropyl)-6-nitroso-3H-imidazo[1,2-a]pyrimidin-5-one

HRID 1995466ノート

反応式

HRID 1995466 の反応式
[CH3:1][CH:2]([CH3:19])[CH2:3][N:4]1[C:12]2[NH:11]C=[N:9][C:8]=2[C:7](=[O:13])[N:6]2[CH2:14][C:15]([CH3:18])([CH3:17])[N:16]=[C:5]12.Cl.CSC1NCC(C)(C)N=1.CC(C)CN.ClC1C=CC(CN)=CC=1.N(=C(C#N)C(OCC)=O)[OH:45].S(S([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].[OH-].[Na+]>C(O)=O>[NH2:11][C:12]1[N:4]([CH2:3][CH:2]([CH3:19])[CH3:1])[C:5]2[N:6]([CH2:14][C:15]([CH3:18])([CH3:17])[N:16]=2)[C:7](=[O:13])[C:8]=1[N:9]=[O:45]

参加物

9

反応物 7

HCID 6558IsobutylamineHCID 14798Sodium HydroxideHCID 660364-ChlorobenzylamineHCID 146045Sodium dithionateHCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateHCID 178448423HCID 178448423、化合物HCID 1785034432-Methylthio-4,4-dimethyl-2-imidazoline hydrochloride

生成物 1

HCID 1784484247-amino-2,2-dimethyl-8-(2-methylpropyl)-6-nitroso-3H-imidazo[1,2-a]pyrimidin-5-one

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

6,7-DIHYDRO-4-(2-METHYLPROPYL)-6,6-DIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE.- 7-Amino-2,3-dihydro-2,2-dimethyl-8-(2-methylpropyl)-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one was prepared by reaction of the 2-methylthio-4,4-dimethyl-2-imidazoline hydrochloride with 2-methylpropylamine according to the method of Procedure 103 by substitution of the latter for p-chlorobenzylamine. The reaction product from this step was then condensed with ethyl oximinocyanoacetate as described in Procedure 103. The resulting nitroso compound was then reduced with sodium dithionate in formic acid and the resulting formylamino compound was cyclized with dilute aqueous sodium hydroxide according to Procedure 100.

出典と根拠

ORDレコード
ord-7304ffcd44004157ba9f1297dac79bb2
出典データセット
uspto-grants-1983_09
特許番号
US04404380

反応ノート

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