Urea → N-(Carbamoylcarbamothioyl)-4-chlorobenzamide
反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]=[C:9]=[S:10])=[O:7])=[CH:4][CH:3]=1.[NH2:13][C:14]([NH2:16])=[O:15]>C1COCC1>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([NH:8][C:9]([NH:13][C:14](=[O:15])[NH2:16])=[S:10])=[O:7])=[CH:4][CH:3]=1参加物
4
実験手順
A solution of 4-Chlorobenzoylisothiocyanate (152.4 g) in THF (500 ml) is added dropwise to a stirred suspension of urea (46.3 g) in THF (750 ml). The reaction mixture is stirred over the weekend. The precipitate is filtered, washed with ether and dried leaving 101.7 g of a white solid, m.p. 155°-158° C. The filtrate is evaporated, filtered, the solid washed with ether and recrystallized from dioxane to give 7.8 g of additional white solid.
後処理
- filtrationThe precipitate is filtered
- washwashed with ether
- customdried
出典と根拠
- ORDレコード
- ord-3e7bd0db155347d1823c5cafa6c36c7e
- 出典データセット
- uspto-grants-1983_09
- 特許番号
- US04406897
反応ノート
読み込み中…