Potassium Carbonate → 7-Benzyl-1-ethoxymethyl-3-methylxanthine

HRID 1996

反応式

HRID 1996 の反応式
[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13](=[O:18])[N:12]([CH3:19])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20]([O:22][CH2:23]Cl)[CH3:21].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:23][O:22][CH2:20][CH3:21])[C:13](=[O:18])[N:12]([CH3:19])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 18523Chloromethyl ethyl etherHCID 6856307-Benzyl-3-methylxanthine

生成物 1

HCID 196891457-Benzyl-1-ethoxymethyl-3-methylxanthine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

20 g (0.078 mol) of 7-benzyl-3-methylxanthine were stirred at 80° C. for 6 hours with 8.8 g (0.094 mol) of ethoxymethyl chloride and 13 g of potassium carbonate in 500 ml of absolute dimethylformamide, the mixture was filtered and concentrated, and the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1).

後処理

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated
  3. customthe residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1)

出典と根拠

ORDレコード
ord-eadaded2a68a4a4683c2b0691e2f1aa0
出典データセット
uspto-grants-1998_03
特許番号
US05728686

関連ノート

読み込み中…