Protocatechuic Acid → Methyl 3,4-Dihydroxybenzoate
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>>[CH3:13][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([OH:1])[CH:3]=1参加物
4
実験手順
A solution of 3,4-dihydroxy benzoic acid (2.8 g) in methanol (150 ml) was refluxed in presence of concentrated hydrochloric acid (0.5 ml) for 12 hrs. After concentrating under reduced pressure, the residue was dissolved in ethyl acetate (150 ml) and washed with water (50 ml) 10% sodium bicarbonate solution (50 ml), brine solution (50 ml) and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.64 g of 3,4-dihydroxybenzoic acid methyl ester. (Yield 86.5%).
後処理
- concentrationAfter concentrating under reduced pressure
- dissolutionthe residue was dissolved in ethyl acetate (150 ml)
- washwashed with water (50 ml) 10% sodium bicarbonate solution (50 ml), brine solution (50 ml)
- dry with materialdried over anhydrous magnesium sulfate
- customRemoval of the solvent under reduced pressure
出典と根拠
- ORDレコード
- ord-10c90eac3e5d4cd08e4480474dc581bb
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745490B2
反応ノート
読み込み中…