化工社化工社 化学情報印刷レポート · 研究参考用
2,4-Dichlorothiazole → (S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichlorothiazole | HCID 12333155 | — |
| 反応物 | (R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate | HCID 86614124 | — |
| 生成物 | (S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate | HCID 67305732 | — |
反応手順
The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 2,4-dichlorothiazole (prepared according to Reynaud, Pierre; Robba, Max; Moreau, Robert C; New synthesis of the thiazole ring; Bulletin de la Societe Chimique de France (1962), 1735-8). MS m/z: 321 (23%, M+1), 265.0 (100%, M−55.1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745484B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-64d1d7ba6333472782ac0a3b90a1e555 |
| 出典メモ | uspto-grants-2010_06 |