Sodium Hydroxide → 6-Chloro-3-nitropyridin-2-ylamine
反応式
[OH-].[NH4+:2].[OH-].[Na+].Cl[C:6]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[C:8]([Cl:15])[N:7]=1>O.C(O)C>[NH2:2][C:6]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[C:8]([Cl:15])[N:7]=1参加物
6
実験手順
A solution of ammonium hydroxide (6.6 g, 0.124 mol) and sodium hydroxide (4.8 g, 0.120 mol) in water (45 mL) was added to 2,6-dichloro-3-nitropyridine (12.0 g, 0.62 mol) in ethanol (240 mL). The reaction was refluxed for 2 h, cooled to room temperature and filtered. The pale yellow solid was dried overnight to give the title compound. 1H NMR (500 MHz, CDCl3) δ 8.87 (d, J=9 Hz, 1H), 7.8 (br s, 1H), 6.73 (d, J=9 Hz, 1H), 5.9 (br s, 1H).
後処理
- temperatureThe reaction was refluxed for 2 h
- filtrationfiltered
- customThe pale yellow solid was dried overnight
出典と根拠
- ORDレコード
- ord-9e379347c1e84156b63bf15302794ca0
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745427B2
反応ノート
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