Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate → Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

HRID 2017

反応式

HRID 2017 の反応式
C([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:29])([O:26][CH2:27][CH3:28])[O:23][CH2:24][CH3:25])[C:13](=[O:30])[N:12]([CH3:31])[C:11]=2[N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:31][N:12]1[C:11]2[N:10]=[CH:9][NH:8][C:16]=2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:29])([O:23][CH2:24][CH3:25])[O:26][CH2:27][CH3:28])[C:13]1=[O:30]

参加物

4

反応物 1

HCID 22446297Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate

生成物 1

HCID 22446315Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

15.7 g (0.035 mol) of diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]-phosphonate were hydrogenated in 150 ml of ethanol over 1 g of palladium (10%) on active carbon at room temperature in the course of 8 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure and the residue was crystallized from diisopropyl ether.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was crystallized from diisopropyl ether

出典と根拠

ORDレコード
ord-ecb037eb61a74599a6353b1d72d5a468
出典データセット
uspto-grants-1998_03
特許番号
US05728686

関連ノート

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