1-(4-Benzylpiperazin-1-yl)piperidin-2-one → 1-Piperazin-1-ylpiperidin-2-one
反応式
C([N:8]1[CH2:13][CH2:12][N:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]2=[O:20])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:11]1([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]2=[O:20])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
To a solution of 1-(4-benzylpiperazin-1-yl)piperidin-2-one (1.0 g) obtained in Example 8a) in methanol (15 mL) was added 20% palladium hydroxide on carbon (containing 50% water, 0.20 g), and the mixture was stirred at room temperature for 15 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the solvent was distilled off under reduced pressure to obtain the title compound (0.65 g, 97%) as a yellow solid.
後処理
- filtrationThe reaction mixture was filtered
- distillationthe solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-e1316c78997f46b29d3de4e1cd7bcd97
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745623B2
反応ノート
読み込み中…