Dimethylformamide → 2-(3-Methylisoxazol-5-yl)acetyl chloride

HRID 20269

反応式

HRID 20269 の反応式
CN(C)C=O.[C:6](Cl)(=O)[C:7]([Cl:9])=[O:8].[CH3:12][C:13]1[CH:17]=[C:16](CC(O)=O)[O:15][N:14]=1>ClCCl>[CH3:12][C:13]1[CH:17]=[C:16]([CH2:6][C:7]([Cl:9])=[O:8])[O:15][N:14]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 41955322-(3-Methyl-1,2-oxazol-5-yl)acetic acid

生成物 1

HCID 123668732-(3-Methylisoxazol-5-yl)acetyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

N,N-Dimethylformamide (few drops), followed by oxalyl chloride (9.5 mL, 106 mmol) were added dropwise to a cooled (10° C.) solution of (3-methyl-isoxazol-5-yl)-acetic acid (5 g, 35.4 mmol) in dichloromethane (50 mL), and the solution was allowed to warm to room temperature. The reaction was stirred for a further 3 hours, then concentrated under reduced pressure. The residue was azeotroped with toluene to afford the title compound.

後処理

  1. additionwere added dropwise to
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was azeotroped with toluene

出典と根拠

ORDレコード
ord-35d1a0ec58494321a176c65bca0fac57
出典データセット
uspto-grants-2010_06
特許番号
US07745630B2

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