Sodium borohydride → (2S,5R)-5-[(1S,2S)-2-Amino-3-(3,5-difluoro-phenyl)-1-hydroxypropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester
反応式
[BH4-].[Na+].[C:3]([O:7][C:8]([N:10]1[C@@H:15]([C@@H:16]([OH:30])[C@@H:17]([N+:27]([O-])=O)[CH2:18][C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=2)[CH2:14][O:13][C@H:12]([O:31][CH2:32][CH3:33])[CH2:11]1)=[O:9])([CH3:6])([CH3:5])[CH3:4]>CO.[Ni](Cl)Cl>[C:3]([O:7][C:8]([N:10]1[C@@H:15]([C@@H:16]([OH:30])[C@@H:17]([NH2:27])[CH2:18][C:19]2[CH:20]=[C:21]([F:26])[CH:22]=[C:23]([F:25])[CH:24]=2)[CH2:14][O:13][C@H:12]([O:31][CH2:32][CH3:33])[CH2:11]1)=[O:9])([CH3:5])([CH3:6])[CH3:4]参加物
5
