Hydrochloric Acid → 4-Benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid

HRID 2035549ノート

反応式

HRID 2035549 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:20]([CH2:33][C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)[C:21]2[CH:22]=[N:23][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:25][CH:26]=2)=[CH:10][C:11]=1[NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:5])C.Cl>C(O)C.[OH-].[Na+].O>[CH2:13]([NH:12][C:11]1[CH:10]=[C:9]([N:20]([CH2:33][C:34]2[CH:35]=[CH:36][C:37]([O:40][CH3:41])=[CH:38][CH:39]=2)[C:21]2[CH:22]=[N:23][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:25][CH:26]=2)[N:8]=[CH:7][C:6]=1[C:4]([OH:5])=[O:3])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 67411902HCID 67411902、化合物

生成物 1

HCID 674139734-Benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid収率 119.4%

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
80 °C

実験手順

3.0 mg of 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid ethylester was dissolved in 1 mL of ethanol, to which 1 mL of 2 mol/L sodium hydroxide in water was added, and stirred at 80° C. for 1 hour. After cooling, hydrochloric acid was added to neutralize the reaction mixture. It was extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 3.4 mg of the title compound containing impurities as a brown oil. Without further purification, this was used in the next reaction as it was.

後処理

  1. additionwas added
  2. temperatureAfter cooling
  3. extractionIt was extracted with chloroform
  4. washthe extract was washed with saturated saline
  5. dry with materialdried on anhydrous sodium sulfate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-f7456403e9224c0db10419b49e71c533
出典データセット
uspto-grants-2013_11
特許番号
US08575153B2

反応ノート

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