Tetrahydrofuran → Tert-butyl 4-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)-3,3-difluoropiperidine-1-carboxylate

反応式

[F:1][C:2]1([F:16])[CH:7]([OH:8])[CH2:6][CH2:5][N:4]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:3]1.CC([O-])(C)C.[K+].C1COCC1.[N:28]1[N:29]=[C:30]([C:37]2[CH:46]=[CH:45][C:44]3[C:39](=[C:40](F)[CH:41]=[C:42]([F:47])[CH:43]=3)[N:38]=2)[N:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=12>CN(C=O)C>[N:28]1[N:29]=[C:30]([C:37]2[CH:46]=[CH:45][C:44]3[C:39](=[C:40]([O:8][CH:7]4[CH2:6][CH2:5][N:4]([C:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[O:10])[CH2:3][C:2]4([F:1])[F:16])[CH:41]=[C:42]([F:47])[CH:43]=3)[N:38]=2)[N:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=12