Potassium Permanganate → HCID 67027109、化合物

HRID 2037318ノート

反応式

HRID 2037318 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1.[O-:11][Mn](=O)(=O)=O.[K+:16]>CC(C)=O>[K+:16].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([O-:11])=[O:10])[CH:3]=1

参加物

4

反応物 2

HCID 516875Potassium PermanganateHCID 67027007(4-Bromo-6-methylpyridin-2-yl)methanol

生成物 1

HCID 67027109HCID 67027109、化合物収率 116%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
40 °C

実験手順

To a solution of (4-bromo-6-methyl-pyridin-2-yl)-methanol (1.31 g, 6.48 mmol) in acetone (150 mL), KMnO4 (2.61 g, 16.5 mmol) is added. The mixture is stirred at 40° C. for 2 h before it is filtered over a sintered glass funnel. The filtrate is evaporated to dryness, and the remaining solid is washed with water and dried under HV to give 4-bromo-6-methyl-pyridine-2-carboxylic acid potassium salt (1.91 g) as a white solid; LC-MS: tR=0.45 min, [M+1]+=217.89.

後処理

  1. filtrationis filtered over a sintered glass funnel
  2. customThe filtrate is evaporated to dryness
  3. washthe remaining solid is washed with water
  4. customdried under HV

出典と根拠

ORDレコード
ord-e27fd69ef6824c73a10558590fe32f5b
出典データセット
uspto-grants-2013_11
特許番号
US08575200B2

反応ノート

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