Triethylamine → 3-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

HRID 2037803ノート

反応式

HRID 2037803 の反応式
CCN(CC)CC.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH2:17])[CH3:16])=[CH:11][CH:10]=1.Cl[CH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22]>O1CCCC1>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH:17][CH2:19][CH2:20][C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:22])[CH3:16])=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 702953-ChloropropiophenoneHCID 1550852(S)-(-)-1-(4-chlorophenyl)ethylamine

生成物 1

HCID 581093723-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

NEt3 (60 mL) followed by (S)-1-(4-chloro-phenyl)-ethylamine (20.5 g) was added to a solution of 3-chloro-1-phenyl-propan-1-one (23.2 g) in tetrahydrofuran (200 mL). The resulting mixture was stirred at room temperature overnight. Then, the solution was concentrated, water (100 mL) was added to the residue, and the resulting mixture was extracted with tert-butyl methyl ether. The combined organic extracts were washed with water and brine and dried (MgSO4). The title compound was obtained after removal of the solvent.

後処理

  1. concentrationThen, the solution was concentrated
  2. additionwater (100 mL) was added to the residue
  3. extractionthe resulting mixture was extracted with tert-butyl methyl ether
  4. washThe combined organic extracts were washed with water and brine
  5. dry with materialdried (MgSO4)

出典と根拠

ORDレコード
ord-8efcffd0815042ea94ac45d8e6700528
出典データセット
uspto-grants-2013_11
特許番号
US08575156B2

反応ノート

読み込み中…