Hydrochloric Acid → 4-[1-(5-Fluoropyrimidin-2-yl)piperidin-4-yl]oxy-1-(4-methylsulfonylphenyl)-2,3-dihydroindole

HRID 203877ノート

反応式

HRID 203877 の反応式
[CH2:45]([Cl:46])[Cl:47].[CH3:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([N:12]2[CH2:13][CH2:14][c:15]3[c:16]([O:21][CH:22]4[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]4)[cH:17][cH:18][cH:19][c:20]32)[cH:10][cH:11]1.[CH:28]([N:29]([CH2:30][CH3:31])[CH:32]([CH3:33])[CH3:34])([CH3:35])[CH3:36].[Cl:37][c:38]1[n:39][cH:40][c:41]([F:44])[cH:42][n:43]1.[ClH:1]>>[CH3:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([N:12]2[CH2:13][CH2:14][c:15]3[c:16]([O:21][CH:22]4[CH2:23][CH2:24][N:25]([c:38]5[n:39][cH:40][c:41]([F:44])[cH:42][n:43]5)[CH2:26][CH2:27]4)[cH:17][cH:18][cH:19][c:20]32)[cH:10][cH:11]1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 5834662-Chloro-5-fluoropyrimidineHCID 690666541-(4-Methylsulfonylphenyl)-4-piperidin-4-yloxy-2,3-dihydroindole

生成物 1

HCID 580170204-[1-(5-Fluoropyrimidin-2-yl)piperidin-4-yl]oxy-1-(4-methylsulfonylphenyl)-2,3-dihydroindole

出典と根拠

ORDレコード
ord-7ca0acdcaa2e461fba42cb6700be3bd9
出典データセット
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

反応ノート

読み込み中…