Trifluoroacetic acid → HCID 71186361、化合物
反応式
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:41]=[CH:40][CH:39]=[CH:38][C:10]=1[O:11][C:12]1[N:17]=[C:16]2[O:18][C:19]([C:21]3[CH:35]=[C:34]([CH3:36])[C:24]([O:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[C:23]([CH3:37])[CH:22]=3)=[N:20][C:15]2=[CH:14][CH:13]=1>ClCCl>[F:8][C:9]1[CH:41]=[CH:40][CH:39]=[CH:38][C:10]=1[O:11][C:12]1[N:17]=[C:16]2[O:18][C:19]([C:21]3[CH:22]=[C:23]([CH3:37])[C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[C:34]([CH3:36])[CH:35]=3)=[N:20][C:15]2=[CH:14][CH:13]=1参加物
4
実験手順
1 ml of trifluoroacetic acid was added to a solution of 170 mg of tert-butyl {4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}acetate in 3 ml of dichloromethane, and the mixture was stirred at room temperature for 16 h. The reaction was then concentrated under reduced pressure, purified by preparative HPLC and freeze-dried. This gave 85 mg (57%) of the title compound.