HCID 66922365、化合物 → 1-Phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

HRID 2039831ノート

反応式

HRID 2039831 の反応式
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]1=[O:17]>C(O)C.[Pd]>[C:11]1([N:4]2[C:5]3=[N:6][CH:7]=[CH:8][CH:9]=[C:10]3[CH2:2][C:3]2=[O:17])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 66922365HCID 66922365、化合物

生成物 1

HCID 149872061-Phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one収率 137.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The compound of step 2 (1.40 g, 3.80 mmol) was dissolved in ethanol (160 ml), and palladium on activated carbon (700 mg, 658 μmol, 10%) was added. The reaction mixture was hydrogenated (1 bar H2) at room temperature overnight. The mixture was filtered over celite, and the filtrate was evaporated under reduced pressure. Column chromatography of the residue on silica gel (EA (50%)/HEP) gave 1.10 g of the title compound.

後処理

  1. customat room temperature
  2. customovernight
  3. filtrationThe mixture was filtered over celite
  4. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3d21900645694cf0bab83775b169a4c2
出典データセット
uspto-grants-2013_11
特許番号
US08580813B2

反応ノート

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