8-(Benzyloxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one → 8-(Hydroxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one

HRID 2040332ノート

反応式

HRID 2040332 の反応式
C([O:8][CH2:9][CH:10]1[CH2:20][CH2:19][C:13]2([O:17][C:16](=[O:18])[NH:15][CH2:14]2)[CH2:12][CH2:11]1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][CH2:9][CH:10]1[CH2:20][CH2:19][C:13]2([O:17][C:16](=[O:18])[NH:15][CH2:14]2)[CH2:12][CH2:11]1

参加物

4

反応物 1

HCID 671267508-(Benzyloxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one

生成物 1

HCID 575765318-(Hydroxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A solution of EXAMPLE 385B (500 mg) in ethanol was added to wet 20% palladium hydroxide on carbon (2500 mg) in a 50 ml pressure bottle. The mixture was stirred at ambient temperature for 3 hours under hydrogen at 30 psi. The mixture was filtered and concentrated to provide the title compound.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-98735a45df8b4764913e432d977be740
出典データセット
uspto-grants-2013_11
特許番号
US08580794B2

反応ノート

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