Ethanol → 3-Phenylprop-2-ynal oxime

HRID 2040838ノート

反応式

HRID 2040838 の反応式
[C:1]1([C:7]#[C:8][CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:12][OH:13].CCO>O>[C:1]1([C:7]#[C:8][CH:9]=[N:12][OH:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 702EthanolHCID 75740PhenylpropynalHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 765430553-Phenylprop-2-ynal oxime収率 100.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of phenylpropargylaldehyde (859 mg, 6.6 mmol), hydroxylamine hydrochloride (4.59 g, 66 mmol), EtOH (48 mL) and water (12 mL) was stirred at r.t. for 24 h. The reaction mixture was diluted with H2O, extracted with Et2O-EtOAc, washed with brine and evaporated to dryness in vacuo affording 0.96 g of the title compound (syn:anti 1:1) as a pasty brownish solid.

後処理

  1. extractionextracted with Et2O-EtOAc
  2. washwashed with brine
  3. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-e5b6604bca9d464cafbb0a7fe9a0e4c7
出典データセット
uspto-grants-2013_11
特許番号
US08580962B2

反応ノート

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