Aluminium lithium hydride → Benzofuran-6-ylmethanamine
反応式
[O:1]1[C:5]2[CH:6]=[C:7]([C:10]#[N:11])[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH2:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[CH:3]=[CH:2][O:1][C:5]=2[CH:6]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
Dissolve benzofuran-6-carbonitrile (0.5 g, 3.28 mmol) in anhydrous THF (10 mL) and add slowly to 1M lithium aluminum hydride in THF (6.56 mL, 6.56 mmol) at ambient temperature. Heat the reaction mixture at 50° C. for 17 h and cool to ambient temperature. Quench the reaction mixture with water until a granular precipitate starts to form and filter through a pad of Celite®. Evaporate the solvent and purify by SCX chromatography to obtain the title compound as a yellow oil (0.4 g, 79%).
後処理
- temperaturecool to ambient temperature
- customQuench the reaction mixture with water until a granular precipitate
- customto form
- filtrationfilter through a pad of Celite®
- customEvaporate the solvent
- custompurify by SCX chromatography
出典と根拠
- ORDレコード
- ord-5ee30c66d2e34749905a68734d2a1220
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08580780B2
反応ノート
読み込み中…