Water → N-cyclopropyl-9-vinyl-9H-purin-6-amine
反応式
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH:11]=[CH2:12].[CH:13]1([NH2:16])[CH2:15][CH2:14]1.O.Cl.C1(N)CC1>C1COCC1>[CH:13]1([NH:16][C:2]2[N:10]=[CH:9][N:8]=[C:7]3[C:3]=2[N:4]=[CH:5][N:6]3[CH:11]=[CH2:12])[CH2:15][CH2:14]1参加物
6
実験手順
6-Chloro-9-vinylpurine (0.54 g, 3 mmol) was mixed with cyclopropylamine (1.71 g, 30 mmol) in THF (10 mL) and the mixture was stirred for 5 h at rt. Water was added to dissolve the white precipitate (cyclopropylamine hydrochloride). The aqueous layer was extracted with ethyl acetate and the combined organic layers were dried over sodium sulfate, concentrated on a rotavap, and then recrystallized from EtOAc/hexanes yielding the desired product.
後処理
- extractionThe aqueous layer was extracted with ethyl acetate
- dry with materialthe combined organic layers were dried over sodium sulfate
- concentrationconcentrated on a rotavap
- customrecrystallized from EtOAc/hexanes yielding the desired product
出典と根拠
- ORDレコード
- ord-0ac4423bf9b744ff8909b50e7798be22
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586566B2
反応ノート
読み込み中…