Nitric Acid → HCID 86669290、化合物
反応式
[N+:1]([O-:4])(O)=[O:2].[CH3:5][O:6][C:7](=[O:20])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[N:10][C:9]=1[O:15][CH2:16][CH:17]([F:19])[F:18]>OS(O)(=O)=O>[CH3:5][O:6][C:7](=[O:20])[C:8]1[CH:13]=[C:12]([N+:1]([O-:4])=[O:2])[C:11]([Cl:14])=[N:10][C:9]=1[O:15][CH2:16][CH:17]([F:19])[F:18]参加物
4
実験手順
Fuming HNO3 (25 mL) is added at rt to 6-chloro-2-(2,2-difluoro-ethoxy)-nicotinic acid methyl ester (10.7 g, 42.5 mmol) in concentrated H2SO4 (50 mL) and stirred for 10 min. The reaction mixture is added dropwise to ice water, stirred and filtered. The filtercake is washed with water and dried at 50° C.
後処理
- stirringstirred
- filtrationfiltered
- washThe filtercake is washed with water
- customdried at 50° C.
出典と根拠
- ORDレコード
- ord-af8a17d0cedc4e7d932596a1f7c8ade4
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586604B2
反応ノート
読み込み中…