Methylamine → HCID 86674501、化合物
反応式
[CH3:1][NH2:2].[CH3:3][O:4][C:5](=[O:21])[C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9](Cl)=[N:8][C:7]=1[O:16][CH2:17][CH:18]([F:20])[F:19]>C1COCC1>[CH3:3][O:4][C:5](=[O:21])[C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([NH:2][CH3:1])=[N:8][C:7]=1[O:16][CH2:17][CH:18]([F:20])[F:19]参加物
4
実験手順
Methylamine (2 M in THF; 32.0 mL, 64.0 mmol) is added at 10° C. to 6-chloro-2-(2,2-difluoro-ethoxy)-5-nitro-nicotinic acid methyl ester (9.1 g, 30.7 mmol) in THF (50 mL). After 1 h at rt the reaction mixture is concentrated, treated with water and filtered. The filtercake is washed with water and dried to give the sub-title compound.
後処理
- concentrationAfter 1 h at rt the reaction mixture is concentrated
- additiontreated with water
- filtrationfiltered
- washThe filtercake is washed with water
- customdried
出典と根拠
- ORDレコード
- ord-35dad638b6824fd2a5c47b5d9eb59c03
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586604B2
反応ノート
読み込み中…