Pivaloyl chloride → N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide

HRID 2042811ノート

反応式

HRID 2042811 の反応式
[C:1](Cl)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]>C1COCC1>[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH:14][C:1](=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

参加物

4

反応物 2

HCID 62493Pivaloyl chlorideHCID 18796740(4-Chloro-3-nitrophenyl)methanamine

生成物 1

HCID 66765017N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

TEA (8.00 mL, 57.5 mmol) followed by pivaloyl chloride (2.80 mL, 22.8 mmol) in THF (25 mL) are added to 4-chloro-3-nitrobenzylamine (5.00 g) in THF (100 mL). The reaction mixture is diluted with THF and stirred at rt for 1.5 h. The mixture is filtered and washed and the filtrate is concentrated.

後処理

  1. filtrationThe mixture is filtered
  2. washwashed
  3. concentrationthe filtrate is concentrated

出典と根拠

ORDレコード
ord-82f6152cfeb04c0cbbad98eea7d5d7ae
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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