Acetonitrile → N-(4-Chloro-3-{[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-2-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide

HRID 2042812ノート

反応式

HRID 2042812 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[N:16]=[C:17]=[S:18].N[C:20]1[C:21]([NH:41][CH3:42])=[N:22][C:23]([O:36][CH2:37][CH:38]([F:40])[F:39])=[C:24]([CH:35]=1)[C:25]([NH:27][C:28]1[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=1)=[O:26].CC#[N:45]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[NH:16][C:17]([NH:45][C:23]1([O:36][CH2:37][CH:38]([F:40])[F:39])[C:24]([C:25](=[O:26])[NH:27][C:28]2[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=2)=[CH:35][CH:20]=[C:21]([NH:41][CH3:42])[NH:22]1)=[S:18]

参加物

4

反応物 3

HCID 6342AcetonitrileHCID 86646343HCID 86646343、化合物HCID 866648925-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

生成物 1

HCID 86669292N-(4-Chloro-3-{[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-2-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide

実験手順

N-(4-Chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide (66 mg, 0.23 mmol) is added to 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide (93 mg, 0.23 mmol) in MeCN (3.5 mL) and stirred at rt overnight. The reaction mixture is filtered and the filtercake is dried.

後処理

  1. filtrationThe reaction mixture is filtered
  2. customthe filtercake is dried

出典と根拠

ORDレコード
ord-1552cf0d52a247f295881565a93008dc
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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