Diisopropylcarbodiimide → HCID 178481212、化合物

HRID 2042819ノート

反応式

HRID 2042819 の反応式
CC(C)N=C=NC(C)C.[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][C:12]=1[NH:25][C:26]([NH:28][C:29]1[CH:30]=[C:31]([C:42](=[O:54])[NH:43][C@H:44]2[CH2:49][CH2:48][C@H:47]([C:50]([F:53])([F:52])[F:51])[CH2:46][CH2:45]2)[C:32]([O:37][CH2:38][CH:39]([F:41])[F:40])=[N:33][C:34]=1[NH:35][CH3:36])=S>CC#N>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][C:12]=1[NH:25][C:26]1[N:35]([CH3:36])[C:34]2=[N:33][C:32]([O:37][CH2:38][CH:39]([F:41])[F:40])=[C:31]([C:42](=[O:54])[NH:43][C@H:44]3[CH2:49][CH2:48][C@H:47]([C:50]([F:53])([F:52])[F:51])[CH2:46][CH2:45]3)[CH:30]=[C:29]2[N:28]=1

参加物

4

反応物 2

HCID 12734DiisopropylcarbodiimideHCID 178482446HCID 178482446、化合物

生成物 1

HCID 178481212HCID 178481212、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

DIC (40 μL, 0.24 mmol) is added to a mixture of N-{4-chloro-3-[3-(trans-4-trifluoromethyl-cyclohexylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-5-ylthioureido]benzyl}-2,2-dimethyl-propionamide (135 mg, 0.20 mmol) and MeCN (3.5 mL). The reaction mixture is stirred at 60° C. overnight, allowed to cool and concentrated. The residue is treated with MeCN, filtered off and dried.

後処理

  1. temperatureto cool
  2. concentrationconcentrated
  3. additionThe residue is treated with MeCN
  4. filtrationfiltered off
  5. customdried

出典と根拠

ORDレコード
ord-f6849ae1aa4b41d5924c0b797305cc8f
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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